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APX-115 freebase

CAS No. 1270084-92-8

APX-115 freebase( Ewha 18278 | APX 115 | APX115 )

Catalog No. M11132 CAS No. 1270084-92-8

APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    APX-115 freebase
  • Note
    Research use only, not for human use.
  • Brief Description
    APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
  • Description
    APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively; shows no inhibitory activities on xanthine oxidase and glucose oxidase; inhibits the responses of BMMs to RANKL, including ROS generation, activation of MAPK and NF-κB, and osteoclast cells differentiation; protects db/db mice from renal injury.Diabetes Preclinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Six-week-old male diabetic db/db mice (C57BLKS/J-leprdb/leprdb)Dosage:60?mg/kg Administration:Oral gavage; per day; for 12 weeks Result:Significantly improved insulin resistance in diabetic mice.
  • Synonyms
    Ewha 18278 | APX 115 | APX115
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NADPH
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1270084-92-8
  • Formula Weight
    279.343
  • Molecular Formula
    C17H17N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (894.97 mM)
  • SMILES
    ——
  • Chemical Name
    3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cha JJ, et al. Lab Invest. 2017 Apr;97(4):419-431. 2. Kwon G, et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18540. 3. Joo JH, et al. Sci Rep. 2016 Mar 15;6:22389.
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  • APX-115

    APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

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